2783 Charter Street
The efficacy and acceptability of ciclopirox olamine (1.5%) and ketoconazole (2%; Nizoral®) shampoos were compared in ‘half-head’ (30 subjects with mild dandruff) and in managed ‘whole-head’ (163 topics with reasonable to severe dandruff and/or seborrhoeic dermatitis) research. Shampooing was twice weekly. In each research, an unmedicated shampoo was used during a 2-three week run-in interval, adopted by a 4-week double-blind, randomized remedy period. There was a 2-week unmedicated shampoo comply with-up period in the entire-head research. A technician assessed the extent and severity of dandruff, the diploma of redness and of scaling resulting from seborrhoeic dermatitis and the area affected, and made a global efficacy analysis. Topics self-assessed dandruff, total scalp itching, itching of the area affected with seborrhoeic dermatitis and dryness/greasiness of their hair, and gave an total opinion of treatment. The half-head research showed that each medicated shampoos considerably reduced dandruff. Scalp itching at four weeks with no variations between treatments. The wholehead study confirmed that ciclopirox olamine, ketoconazole and Apotheke the management (unmedicated shampoo base) each improved dandruff and/or seborrhoeic dermatitis significantly with each medicated shampoos being equally effective and likewise superior to the control shampoo at 4 weeks. Between baseline and Apotheke day 43, the lower in dandruff rating was considerably better for ketoconazole than for ciclopirox olamine with the difference between therapies being important. In each research, farmacie ciclopirox olamine (1.5%) was efficient in the remedy of scalp disorders and was as nicely tolerated as ketoconazole. Apotheke

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